Variability within the human iNOS gene and Achilles tendon injuries: Evidence for a heterozygous advantage effect

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Variability within the human iNOS gene and Achilles tendon injuries: Evidence for a heterozygous advantage effect

The aim of this case control genetic association study was to explore whether two variants within the inducible nitric oxide synthase (iNOS) gene, rs2779249 (C/A) and rs2248814 (A/G), influenced the risk of Achilles tendinopathy in a British population. Design: Candidate gene, case control association study. Method: We recruited 145 individuals diagnosed with Achilles tendon pathology and 132 asymptomatic controls. All participants were genotyped for the iNOS variants using qPCR and significant associations were discovered using a combination of Chi squared and ANOVA type analysis.

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